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Trypsinogen test

Definition

Trypsinogen is a substance that is normally produced in the pancreas and released into the small intestine. Trypsinogen is converted to trypsin. Then it starts the process needed to break down proteins into their building blocks (called amino acids).

A test can be done to measure the amount of trypsinogen in your blood.

Alternative Names

Serum trypsin; Trypsin-like immunoreactivity; Serum trypsinogen; Immunoreactive trypsin

How the Test is Performed

A blood sample is taken from a vein. The blood sample is sent to a lab for testing.

How to Prepare for the Test

There are no special preparations.

How the Test will Feel

Why the Test is Performed

Normal Results

Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.

What Abnormal Results Mean

Increased levels of trypsinogen may be due to:

  • Abnormal production of pancreatic enzymes
  • Acute pancreatitis
  • Cystic fibrosis
  • Pancreatic cancer

Low or normal levels may be seen in chronic pancreatitis.

Risks

Other risks associated with having blood drawn are slight but may include:

  • Excessive bleeding
  • Fainting or feeling light-headed
  • Hematoma (blood accumulating under the skin)
  • Infection (a slight risk any time the skin is broken)

Considerations

Other tests used to detect pancreas diseases may include:

  • Serum amylase
  • Serum lipase

References

Forsmark CE. Chronic pancreatitis. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisinger and Fordtran's Gastrointestinal and Liver Disease. 9th ed. Philadelphia, Pa: Saunders Elsevier; 2010:chap 59.

Tenner S, Steinberg WM. Acute pancreatitis. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisinger and Fordtran's Gastrointestinal and Liver Disease. 9th ed. Philadelphia, Pa: Saunders Elsevier; 2010:chap 58.


Review Date: 1/22/2013
Reviewed By: George F. Longstreth, MD, Department of Gastroenterology, Kaiser Permanente Medical Care Program, San Diego, California. Also reviewed by A.D.A.M. Health Solutions, Ebix, Inc., Editorial Team: David Zieve, MD, MHA, Bethanne Black, Stephanie Slon, and Nissi Wang.
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