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Acquired platelet function defect
Acquired qualitative platelet disorders; Acquired disorders of platelet function
Other causes include:
- Abnormal menstrual periods
- Heavy menstrual periods
- Prolonged menstrual bleeding (more than 5 days per menstrual period)
- Abnormal vaginal bleeding
- Bleeding in the urine
- Bleeding under the skin or in the muscles (soft tissues)
- Gastrointestinal bleeding
- Prolonged bleeding, easy bruising
- Skin rash
- Pinpoint red spots (petechiae)
Exams and Tests
Treatment is aimed at the cause of the problem.
- Bone marrow disorders are treated with platelet transfusions or removing platelets from the blood (platelet pheresis). Chemotherapy is can used to treat an underlying condition that is causing the problem.
- Platelet function defects caused by kidney failure are treated with dialysis or a drug called desmopressin (ddAVP).
- Platelet problems caused by a certain medicine are treated by stopping the drug.
Most of the time, treating the cause of the problem corrects the defect.
- Prolonged bleeding
- Severe anemia
When to Contact a Medical Professional
Call your health care provider if:
- You have bleeding and do not know the cause
- Your symptoms get worse
- Your symptoms do not improve after you are treated for an acquired platelet function defect
Diz-Kucukkaya R, Lopez JA, Acquired disorders of platelet function. In: Hoffman R, Benz EJ Jr, Silberstein LE, Heslop HE, Weitz JI, eds. Hematology: Basic Principles and Practice. 6th ed. Philadelphia, PA: Saunders Elsevier; 2012:chap 132.
Ragni MV. Hemorrhagic Disorders: Coagulation Factor Deficiencies. In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine. 24th ed. Philadelphia, PA: Saunders Elsevier; 2011:chap 177.
Reviewed By: Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital. Also reviewed by A.D.A.M. Health Solutions, Ebix, Inc., Editorial Team: David Zieve, MD, MHA, Bethanne Black, Stephanie Slon, and Nissi Wang.